- 109 subjects monitored for acute kidney injury following cardiac surgery using αGST and πGST
This publication was presented at the American Society of Nephrology in November 2008. The objective of the study was to evaluate the utility of urinary alpha (α) and pi (π) Gluthathione S-Transferase (GST) as early markers of Acute Kidney Injury (AKI) following adult cardiac surgery. Clinical characteristics of the 109 study subjects are detailed here.
The study concluded that Urinary α-GST may serve as an early diagnostic biomarker of AKI following adult cardiac surgery. Urinary π-GST is a promising early biomarker of distal tubular injury and may reliably predict the development of severe AKI as measured by AKIN network Stage 3. Additionally, it may serve a role as a severity marker of AKI at the time of clinical creatinine increase. Urinary α-GST and π-GST are promising biomarkers of the development and severity of AKI following Adult Cardiac surgery.
2) Comparison of Novel Early Biomarkers of Acute Kidney Injury (AKI) to predict the Course and Severity of AKI Developing after Cardiac Surgery
JL Koyner MD, P Devarajan MD, VS Vaidya PhD, and Murray, PT. (2009). Poster presented at the World American Society of Nephrology, San Diego, October 2009
- Evaluating the utility of urinary biomarkers Cystatin C (CyC), Neutrophil Gelatinase Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1), Hepatocyte Growth Factor (HGF), Pi-Glutathione-S-Transferase (π-GST) and α-GST as markers of Acute Kidney Injury severity, at the time ofclinical creatinine increase, following adult cardiac surgery.
