Summary
- Serum αGST is more sensitive than traditional biomarkers in detecting the acute effects of alcohol.
- Alcoholics have low serum αGST levels between consuming alcohol.
- Serum αGST can be used to study the effects of alcohol in animal models.
- Serum collagen IV correlates with extent of liver fibrosis.
- Serum collagen IV levels decline in abstaining alcoholics.
Alpha GST Articles
1) Improved detection of acute drug-induced liver toxicity by measurement of serum alpha glutathione S-transferase in Cynomolgus monkeys.
Mohr, S. et al. 2002. Poster presented at the Society of Toxicology meeting. March 2002
- Following alcohol administration, αGST rose.
- ALT, AST, GGT and ALP did not change.
2) Alcohol hepatic toxicity in rat: evidence of the utility of gastric ethanol metabolism.
Battiston, L., Moretti, M., Tulissib, P., Fanni-Canelles, M. and. Pozzato, G. (1996).
International Hepatology Communications 6 661-70.
- Following alcohol adminstration, αGST rose.
- ALT, AST, GGT and ALP did not change.
- αGST could demonstrate the differing toxicities of different methods of alcohol administration.
3) Changes in plasma glutathione S-transferase B1 concentration after alcohol ingestion in man: a measure of hepatocellular sensitivity to chronic alcohol excess.
Hayes, P.C., Hayes, J.D., Hussey, A.J., Bouchieru, I.A.D. and Beckett, G.J. (1990). Clin. Chem. Enzyme Commun. 2 189-194.
- Normal subjects who consume an acute dose of alcohol do not show an increase in αGST; alcoholics do.
- Between consuming alcohol, alcoholics have low serum αGST levels.
Serum Collagen IV Articles
1) Serum markers for hepatic fibrosis in alcoholic liver disease: which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?
Tsutsumi, M., Takase, S., Urashima, S., Ueshima, Y., Kawahara, H. and Takada, A. (1996) Alcohol Clin. Exp. Res. 20(9) 1512-7.
- Collagen IV correlated most closely with the extent of hepatic fibrosis.
- Serum collagen IV levels declined in abstaining alcoholics.
- Serum collagen IV was he best indicator of therapy response.
