Argutus have been the leading manufacturer of quality alpha GST assays over the last 10 years. Please select from the assay options below
Serum α-glutathione S-transferase (GST) is a uniquely sensitive and highly specific biomarker for hepatotoxicity/hepatocyte injury. Unlike the aminotransferases which are predominantly found in the periportal hepatocytes, α-GST is found in hepatocytes throughout the periportal and centrilobular regions of the liver. This uniform hepatic distribution, together with a high intracellular (cytoplasmic) level means that α-GST is a much more sensitive, earlier and specific indicator of hepatotoxicity than the traditionally measured aminotransferases (Hum Exp Toxicol 1997; 16:154–7).
Currently, GSTs are the most sensitive and region-specific biomarkers for the detection of tubular injury. GSTs are found in high concentrations in the cells of the renal tubules. They are readily released into the urine during injury and, thus, are excellent biomarkers for tubular injury resulting from nephrotoxicity, ischaemic injury, transplant rejection, proteinuria and diabetic renal tubular injury.