Summary
- The Argutus Medical OxyDNA Test can be used to study oxidative DNA damage in a many cancer models.
Selected Articles
1) Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H202 Exposure
Cho, N.I.L., Boxiao, S.D., Chi, G.. Japanese Cancer Association 66th annual meeting October 3 - 5, 2007 Pacifico, Yokohama, Japan.
2) Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA.
Kropotov, A., Serikov, V., Suh, J., Smirnova, A., Bashkirov, V., Zhivotovsky, B. and Tomilin, N.. (2006).
FEBS Journal 273 (12) 2607–2617.
3) Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a CHK1-dependent G2 checkpoint.
Macip, S., Kosoy, A., Lee, S.W., O'Connell, M.J. and Aaronson, S.A. (2006). Oncogene 25 6037–6047.
4) In situ identification of oxidative DNA damage in U937 cells treated by various pro-apoptotic compounds using immunofluorescent detection of 8-oxoguanine by flow cytometry.
Monier S., Nacol-Lizard, S., Chaouchi, N., Gambert, P. and Lizard G. Immunology and Leukemias Groupe d'Etude Immunologique des Leucémies, Dijon, France January 31-February 2, (2002). Journal of Hematology 87(1) 8-9.
5) 5-Hydroxytryptamine drives apoptosis in biopsy like Burkitt lymphoma cells: Reversal by selective serotonin reuptake inhibitors.
Serafeim, A., Grafton, G., Chamba, A., Gregory, C.D. Blakely, R.D. Bowery, N.G., Barnes, N.M. and Gordon, J. (2002).
Blood. 99 2545-2553.
6) Tumor necrosis factor-α increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.
Babbar, N. and Casero Jr, R.A. (2006). Cancer Res. 66(23) 11125-30.
7) Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.
Martirosyan, A., Leonard, S., Shi, X. Griffith, B. Gannett, P. and Strobl, J.
The Journal of Pharmacology and Experimental Therapeutics 317(2) 546–552.
8) FACS analysis of oxidative stress induced on tumour cells by SERMs
Osella, D., Mahboobi, H., Colangelo, D., Cavigiolio, G., Vessieres, A. and Jaouen, G. (2005). Inorganica Chimica Acta 358 1993–1998.
9) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
Perillo, B., Ombra, M.N., Bertoni, A., Cuozzo, C., Sacchetti, S., Sasso, A., Chiariotti, L., Malorni, A. Abbondanza, C., Avvedimento, Enrico V. (2008). Science 319 202-206.