Summary
- Urinary αGST is a sensitive indicator of contrast media induced nephropathy.
- Urinary αGST release correlates with the dose of medium administered.
- Urinary αGST release can indicate treatment differences.
- Urinary αGST release indicates the time course of renal effects.
Selected Articles
1) Renal effects of N-acetylcysteine in patients at risk for contrast nephropathy: decrease in oxidant stress-mediated renal tubular injury.
Drager, L.F., Andrade, L., Barros de Toledo, J.F., Laurindo, F.R., Machado César, L.A. and Seguro, A.C. (2004).
Nephrol. Dial. Transplant. 19(7) 1803-7
- 24 subjects randomised to receive either N-acetyl cysteine or placebo.
- N-acetylcysteine led to lower urinary levels of αGST.
2) Urinary alpha glutathione S-transferase levels before and after radiocontrast exposure: Effect of Amlodipine administration
Arici, M., Altun, B., Erdem, Y. et al. (1997) Nephrology, Dialysis Transplantation 12(9) 1997
- 24 patients examined for urinary levels of αGST before and after radiocontrast exposure. Patients undergoing coronary angiography were randomised to either placebo (N = 14) or Amlodipine (n=10) starting 14 days prior to coronary angiography.
- Subjects exposed to contrast medium showed elevated urianry αGST in the absence of changes in serum creatinine.
- Amlodipine administration prior to radiocontrast exposure seems to be ineffective in preventing the contrast induced tubular insult.
3) A Prospective Study of urinary Ligandin in Patients at Risk of Renal Tubular Injury
Sherman, R.A., Feinfeld, D.A. et al. (1985) Uremia Investigation 8 111-115
- 6 subjects received contrast media.
- Only subjects receiving more than 30g contrast iodine showed an increase in urianry αGST (Ligandin).