Summary
- Diabetics have increased levels of oxidised DNA in peripheral lymphocytes.
Selected Articles
1) Pro-oxidant effect of α-tocopherol in patients with Type 2 Diabetes after an oral glucose tolerance test – a randomised controlled trial.
Mark S Winterbone, Mike J Sampson, Shikha Saha, Jackie C Hughes and David A Hughes. (2007). Cardiovascular Diabetology 6:8
- 19 type 2 diabetes subjects were randomised into two groups taking either 1200 IU/day of α-tocopherol or a matched placebo for 4 weeks. On day 0 and 29 of this study oxidative DNA damage was assessed in mononuclear cells from fasted blood samples and following a 2 h glucose tolerance test (GTT).
2) Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes.
Sampson, M.J. et al. (2006). Diabetes Care 29 283–289.
- In diabetics, increased oxidised DNA in peripheral white blood cells is associated with shorted telomeres.