Summary
- The Argutus Medical OxyDNA Test can be used to study oxidative DNA damage resulting from many environmental toxins.
Selected Articles
1) The oxidative DNA damage analysis in coke oven workers
Adamekt, B. Kasperczyk, J., Wiczkowski, A., Stgplewski, Z., Strzelczyk, J. and Gawront, K. (2004).
Polish Journal of Environmental Studies 13(11) 29-31.
2) The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells.
Schaaf, G et al. (2002). Biochim. Biophys. Acta. 1588(2) 149-58.
- Exposure to the fungal toxin Ochratoxin caused oxidative DNA damage.
- Addition of the anti-oxidant N-acetyl cysteine reduced DNA oxidation.
- Ochratoxin is suspected in being involved in the pathology of endemic Balkan nephropathy.
3) Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1. A study of adolescents in a high risk region for hepatocellular carcinoma in China.
Shen, H.-M., Liu, Z.-M., Yan, L.-N., Peng, M.-H., Li, L.-Q. Liang, R.-X., Wei, Z.-L. Halliwell, B. and Ong, C.N. (2003).
World J. Gastroenterol. 9(10) 2186-2193.
- OxyDNA correlated highly with the DNA repair enzyme hOGG1.
- Reproducibility of the Argutus Medical OxyDNA Test was better than 90% and variability under 10%.
4) Protective effect of metallothioneins against oxidative stress evaluated on wild type and MT-null cell lines by means of flow cytometry
Colangelo, D., Mahboobi, H., Viarengo, A. and Osella, D. (2004). Biometals. 17(4) 365-70.
- Metallothionins protect cells against cadmium induced oxidative DNA damage.
5) Cell type-specific effects of asbestos on intracellular ROS levels, DNA oxidation and G1 cell cycle checkpoint
Kopnin, P.B., Kravchenko, I.V., Furalyov, V.A., Pylev, L.N. and Kopnin, B. P. Oncogene 23(54) 8834–8840.
- The Argutus Medical OxyDNA Test can distinguish between the relative sensitivities of fibroblasts and mesothelial cells to chrysotile.
- 8-oxodeoxyguanine staining increases in dose response fashion to exposure to chrysotile.