Fertility Monitoring

Summary

• Increased staining of sperm for oxidative DNA damage is associated with decreased fertility and blastocyst viability.

 

Selected Articles

 

1) Exposure of bovine sperm to pro-oxidants impairs the developmental competence of the embryo after the first cleavage.
Silva, P.F.N., Gadella, B.M., Colenbrander, B. and Roelen, B.A.J. (2007). Theriogenology. 67 609–619.

•  Increased oxidative DNA staining is associated with decreased blastocyst viability.

 

2) Oxidative degradation of sperm DNA during in-vitro storage.
Watson, P.F. and Cariese, S. (2002). 9th International Spermatology Conference, Cape Town, October 2002.

• In frozen semen, increased oxidative DNA damage was associated with decreased sperm viability.

 

3) Effects of cryopreservation on human sperm, deoxyribonucleic acid integrity.
Zribi, N., Chakroun, N.F., El Euch, H. Gargouri, J., Bahloul, A. and Keskes, L.A.  Fertility Sterility (in Press)

• Cryopreservation of sperm is associated with oxidative DNA damage.

• Increased staining with the Argutus Medical OxyDNA Test is associated wth decreased fertility.