Summary
- Perfusate αGST is the best biochemical predictor of graft non-function.
Clinical studies
1) The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors.
Wight, J., Chilcott, J., Holmes, M. and Brewer, N. (2003). Health Technol Assess 7(25).
- A review of the cost effectiveness of machine perfusion of kidneys.
- αGST was the most promising biochemical test of graft viability.
2) Glutathione S‑transferase as predictor of functional outcome in transplantation of machine preserved non-heart-beating donor kidneys.
Daeman, J.-W. H.C. et al. (1997). Transplantation 63(1) 89-93.
- 67 Non-Heart-Beating-Donor kidneys were studied.
- αGST in the perfusate was the best individual indicator of the viability of non-heart beating donor kidneys.
3) Viability assessment of Non-Heart-Beating Donor kidneys by alpha glutathione S‑transferase in the machine perfusate.
Kievit, J.K. et al. (1997). Transplantation Proceedings 29 1381-1383.
- 107 renal transplants studied.
- A low perfusate αGST had a predictive value of 98% for a functioning kidney.
Preclinical Studies
1) Effect of anti‑LFA‑1 monoclonal antibody on post - ischemic injury in isolated kidney reperfusion
Storck, M., Kübler, H., Prestel, R., Techt, B., Tiollier, J., Martin, X. and Abendroth, D. (1998). Presented at the 17th Annual Meeting of the American Society of Transplant Physicians (ASTP), May 9-13, 1998, Chicago.
- 5 cynomolgus monkey kidneys perfused with anti-IFA-1, compared with 4 controls.
- A monoclonal antibody against the adhesion molecule LFA-1 (Odulimomab) lead to lower perfusate αGST matching electron-microscopically confirmed reduced epithelial injury.
