About Pi-GST as a Biomarker

URINE STUDIES
πGST is located in the distal tubules of the human kidney whereas alpha GST (αGST) is confined mainly to the proximal tubules. πGST is released into the urine of normal individuals as confirmed by enzyme immunoassay. Any event which precipitates distal tubular damage may cause increased release of πGST into urine and elevations of urinary πGST levels have been shown to be indicative of distal tubule damage in renal transplant rejection nephrotoxicity, infection, diabetes and chronic renal injury. The release of αGST has been shown to be associated with proximal tubular damage, thus simultaneous measurement of πGST and αGST may allow discrimination between proximal and distal tubular damage.
 

References

For references see our publications section, here