Selected Articles
1) Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells
Panayiotidis, M.I., Rancourt, R.C., Allen, C.B., Riddle, S.R. Schneider, B.K., Ahmad, S. and White, C.W. (2004).
Antioxidants & Redox Signaling 6(1) 129-136.
- Oxidative DNA damage increases with length of exposure to 95% oxygen.
2) Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression
Maniscalco, W.M., Watkins, R.H., Roper, J.M., Staversky, R., and. O’Reilly, M.A. (2005). Pediatr. Res. 58 549–556.
- Cell sections stained with the Argutus Medical OxyDNA probe.
- Oxidative DNA staining initiallly localised to mitochondria.
- Increased oxidative DNA staining associated with increased p53 expression.
3) In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells
Roper, J.M., Mazzatti, D.J., Watkins, R.H., Maniscalco, W.M., Keng, P.C. and O’Reilly, M.A. (2004).
Am. J. Physiol. Lung Cell Mol. Physiol. (286) 1045–1054.
- Exposure of lung epithelial cells to high oxygen contentrations leads to oxidative DNA damage.
- The Argutus Medical OxyDNA Test offers a valuable tool to study the pulmonary effects of intensive care.
- Cell sections stained with the Argutus Medical OxyDNA probe.
- Oxidative DNA staining initially localised to mitochondria.
- Alveolar cells showed increased oxidative damage with time.