Summary
- Alpha GST (αGST) and Pi GST (πGST) are localised to distinct parts of the nephron.
- By the assay of a panel of biomarkers, injury to different parts of the nephron can be studied independently and simulataneously.
- In-vitro studies can indicate preclinical and clinical toxicity.
Selected Articles
1) Use of human organ slices to evaluate the biotransformation and drug-induced side-effects of pharmaceuticals.
Vickers, A.E.M. (1994). Cell Biology and Toxicology 10, 407-414.
- The release of αGST from tissue slices can distinguish the relative toxicities of drug candidates.
2) Changes in human liver and kidney slice function related to potential side-effects in the presence of biotransformation of 4 cyclosporin derivatives, CSA, IMM. OG and PSC.
Vickers, A.E.M. et al. (1998) In-vitro and Molecular Toxicology 11(2), 119-131.
- The simultaneous assay of αGST and πGST, enables the proximal and distal tubules to be studied independently.
