Summary
- Urinary GST levels change in advance of serum creatinine.
- Uncomplicated transplantation is acompanied by rapidly falling levels of GSTs.
- Acute tubular necrosis is associated with elevated levels of both αGST and πGST.
- Proximal tubular toxicity was associated with elevation of αGST.
- Rejection is associated with elevated πGST.
- Urinary collagen IV may be a biomarker for chronic rejection.
Selected Articles
Human Studies
1) Activity of glutathione S-transferases in the urine of kidney transplant recipients during the first week after transplantation.
Polak, W.P., Kosieradzki, M., Kwiatkowski, A., Danielewicz, R., Lisik, W., Michalak, G., Paczek, L., Lao, M., Walaszewski, J. and Rowinski, W.A. (1999). Ann. Transplant. 4(1) 42-5.
- 50 organs from Non-Heart Beating Donors studied.
- ΠGST was elevated in subjects with rejection.
- Both αGST and πGST were elevated in subjects with acute tubular necrosis.
2) Urinary pi-class glutathione transferase as an indicator of tubular damage in the human kidney.
Sundberg, A.G., Appelkvist, E.L., Bäckman, L. and Dallner, G. (1994). Nephron. 67(3) 308-16.
- 109 renal transplant recipients followed.
- Urinary GST levels changed in advance of serum creatinine.
- Uncomplicated transplantation was acompanied by rapidly falling levels of GSTs.
- Acute tubular necrosis was associated with elevated levels of both αGST and πGST.
- Proximal tubular toxicity was associated with elevation of αGST.
- Rejection episodes were associated with elevated πGST.
3) Measurement of urine collagen type IV after kidney transplantation.
Tonsho, M., Sawada, T., Utsumi, K., Tojimbara, T., Nakajima, I., Fuchinoue, S. and Agishi, T. (2000).
Transplant. Proc. 32(7) 1780.
- 30 transplant recipients investigated.
- Acute rejection was associated with increased urinary collagen IV.
- Urinary collagen IV may be a biomarker for chronic rejection.
Animal Studies
1) Endotelin ETA and ETB receptor antagonism during cold preservation in renal transplantation.
Hammad, F.T., Davis, G., Zhang, X.Y. and Wheatley AM. (2001). Transplantation. 71(5) 619-27.
- 14 Rat kidneys exposed to cold ischemia with endothelin antagonists, 6 controls.
- Post operative urinary levels of αGST and GSTYb1 were lower in those rats which received kidneys treated with ETA antagonists.
- The postoperative urinary GST levels were lowest in rats that survived longest.
