Summary
- αGST can identify adverse hepatic events in advance of traditional biomarkers.
- The rapid fall in αGST following successful therapy can optimise and reduce therapy.
- Utilising αGST can reduce patient morbidity and mortality.
- Utilising αGST can reduce patient costs.
- Biliary πGST is a sensitive indicator of liver status.
Selected Articles
1) Randomized trial to evaluate the clinical benefits of serum alpha-glutathione S-transferase concentration monitoring after liver transplantation.
Hughes, V.F., Trull, A.K., Gimson, A., Friend, P.J., Jamieson, N., Duncan, A., Wight, D.G., Prevost, A.T. and Alexander, G.J. Transplantation. 1997. Nov 27 64(10) 1446-52.
- 60 transplants in 49 subjects monitored. Utitlising serum αGST to monitor subjects resulted in:
- Reduced mortality.
- Reduced morbidity.
- Shortened patient stay.
2) Determination of alpha- and Pi-glutathione-S-transferase will improve monitoring after liver transplantation
Platz, K.P., Mueller, A.R., Haller, G.W., Müller, C., Wenig, M., Neuhaus, R., Kottgen, E. and Neuhaus, P.
Transplant. Proc. 1997 Nov 29(7) 2827-9.
- 85 transplants in 81 patients followed.
- Serum αGST is an excellent indicator of ischaemia-reperfusion injury.
- Serum αGST is an excellent indicator of the severity of rejection episodes.
- Biliary πGST is an excellent indicator of ischaemia-reperfusion injury.
- Biliary πGST is an excellent indicator of the severity of rejection episodes.
3) Evaluation of an enzyme-immunometric assay for serum alpha-glutathione S-transferase.
Rees, G.W., Trul,l A.K. and Doyle, S. Ann. Clin. Biochem. 1995 Nov 32(6) 575-83.
- A review of the assay of αGST and its use in liver transplantation
- Serum alpha GST is a better discriminant of acute changes in liver function than conventional tests
4) Serum alpha-glutathione S-transferase--a sensitive marker of hepatocellular damage associated with acute liver allograft rejection.
Trull, A.K., Facey, S.P., Rees, G.W., Wight, D.G., Noble-Jamieson, G., Joughin, C., Friend, P.J. and Alexander, G.J. Transplantation. 1994 Dec 27 58(12) 1345-51.
- 58 liver transplants in 45 patients monitored using alpha GST.
- GST was the first parameter to rise when an event occurred.
- αGST was the first parameter to fall as it was resolved.
- αGST was the best indicator of therapeutic response.
- αGST is a more stable biomarker in the absence of hepatic injury.