Summary
- Oxidative DNA damage increases with increasing exposure to radiation.
- Initial DNA damage seems to be to the mitochondria.
- 8-oxoguanine staining increases with radiation dose.
- 8-oxoguanine staining continues to increase for some hours after radation expossure ceases.
- H2O2 enhances the effects of radiation, possibly by damaging mitochondria.
Selected Articles
1) Radiation induced oxidative DNA damage, 8-oxoguanine in human peripheral lymphocytes
Ogawa, Y. et al. (2003). International Journal of Molecular Medicine 11 27-32.
2) Radiation induced reactive oxygen species formation prior to oxidative DNA Damage, in human peripheral lymphocytes
Ogawa, Y. et al. (2003). International Journal of Molecular Medicine 11 149-152.
3) Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: A potent role of hydrogen peroxide as a new radiosensitizer
Ogawa, Y., Takahashi, T., Kobayashi, T., Kariya, S., Nishioka, A., Ohnishi, T., Saibara, T., Hamasato, S., Tani, T., Seguchi, H., Yoshida, S. and Sonobe, H. (2003). International Journal of Molecular Medicine 12 845-850.
4) Analysis of 8-hydroxydeoxyguanosine 5’-monophosphate (8-OH-dGMP) as a reliable marker of cellular oxidative DNA damage after γ-irradiation
Mei, N., Tamae, K., Kunugita, N., Hirano, T. and Kasai, H. (2003). Environ. Mol. Mutagen. 41 332-338.