1) A new urinary marker predicts progression to albuminuria and risk of death in patients with type 1 diabetes mellitus.
Nielsen, et. al., Diabetes Care 33, 1320-1324 (2010)
- 165 patients who had been diagnosed as having T1DM between 1979-1984 had samples analysed after 1990.
- Results demonstrate that urinary levels of L-FABP could potentially be used to predict meaningful clinical endpoints in patients with T1DM
2) Urinary liver fatty acid-binding protein: another novel biomarker of acute kidney injury.
McMahon BA, Murray PT. Kidney Int. 2010 Apr;77(8):657-9.
Liver fatty acid-binding protein (L-FABP) binds selectively to intracellular free unsaturated fatty acids and lipid peroxidation products during hypoxic tissue injury. Urinary L-FABP is a potential biomarker for the detection and assessment of acute kidney injury (AKI). Ferguson et al. have demonstrated in a cross-sectional study that urinary L-FABP is an excellent biomarker of AKI and may be useful in predicting dialysis-free survival. This study did not assess utility for early diagnosis of AKI.