Summary

• Renal injury in non-diabetic obese subjects may have a different pathology to diabetic nephropathy.
• The increase in urinary αGST indicates early proximal tubular injury.

Selected Article

1) The detection of obesity-related nephropathy using novel urinary biomarkers.
Bashir, M., Cawood, T., Brady, J. and Murray, J.B. Poster presented at the World Congress of Nephrology, Milan, May 22-26, 2009

• 17 obese subjects with normal serum creatinine were studied.
• 59% had elevated αGST, 29% elevated πGST and 24% elevated collagen IV.
• Obese subjects have a high frequency of renal tubular injury, particularly to the proximal tubule.