Summary
- Hepatic effects of cardiobypass surgery can be studied using serum αGST.
- Serum αGST can be used to study the hepatic effects of surgical and therapeutic interventions.
Selected Articles
1) A prospective randomized study to evaluate changes in alpha-GST as a novel marker of hepatocellular necrosis in patients at high-risk of hepatic injury undergoing coronary revascularization with and without cardiopulmonary bypass.
Varghese, D., Varghese, B., Kelley, K., Hanson, M., Wood, P., Hett, D., Velissaris, T. and Ohri, S.K. (2007). Abstracts of the 53rd Annual Conference of IACTS, Feb 2007. Indian Journal of Thoracic and Cardiovascular Surgery. Supplement 2007; 23 63
- 40 subjects undergoing cardiac surgery.
- Serum αGST increased during surgery.
2) Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function.
Kumle, B., Boldt, J., Suttner, S.W., Piper, S.N., Lehmann, A. and Blome, M. (2003). Ann. Thorac. Surg. 75(5)1558-64.
- 30 subjects indergoing aorto-coronary bypass grafting.
- αGST levels significantly higher and MEGX extraction lower following 80 minutes on cardiopulmonary bypass.
3) Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients.
Boldt, J., Brosch, C., Piper, S.N., Suttner, S., Lehmann, A. and Werling, C. (2001) Crit. Care Med. 29(5) 952-8
- 40 patients undergoing cardiac surgery.
- Pentoxifyllin could reduce hepatic injury as indicated by reductions in post-operative αGST and improved hepatic function as measured by monoethylglycinexylidide test.
4) Indocyanine green clearance and hepatic function during and after prolonged anaesthesia: comparison of halothane with isoflurane.
Murray, J.M., Rowlands, B.J. and Trinick, T.R. (1992). Br. J. Anaesth. 68(2) 168-71.
- 20 consecutive subjects undergoing head or neck surgery.
- Serum αGST levels higher folowing halothane, AST levels did not change.
- αGST elevations were associated with decreased iodocyanine green clearance.
