Summary

• Serum αGST is a sensitive indicator of hepatocellular injury following trauma or sepsis.
• Serum αGST is an earlier indicator of hepatic injury than transaminases.
• Serum αGST can be used to study the effects of therapeutic interventions.

Selected Articles

1)  G protein-coupled receptor 30-dependent protein kinase A pathway Is critical in nongenomic Effects of Estrogen in Attenuating Liver Injury after Trauma-Hemorrhage.
Hsieh, Y.C., Yu, H.P., Frink, M., Suzuki, T., Choudhry, M.A., Schwacha, M.G. and Chaudry, I.H. (2007). The American Journal of Pathology, 170(4) 1210-8.
 

• Liver injury studied in groups of 6-8 rats.
• Serum αGST could show the hepatoprotective effects of estrogen.
  

2) Plasma a-Glutathione S-Transferase: A Sensitive Indicator of Hepatocellular Damage During Polymicrobial Sepsis.
Koo, D.J., Zhou, M., Chaudry, I.H. and Wang P. (2000). Arch. Surg. 135(2) 198-203.
 

• Plasma αGST rose 5 hours post surgery, lactate did not increase until 20 hours.
• Assay of αGST could aid in the earlier detection and therapy of the hepatic effects of sepsis.
  

3) Plasma glutathione S-transferase as an early marker of posttraumatic hepatic injury in non-human primates.

Redl, H., Schlag, G., Paul, E. and Davies, J. (1995). Shock. 3(6) 395-7.
 

• Haemorrhagic shock induced in six male baboons.
• αGST was an earlier indicator of hepatic injury following traumatic-haemorrhagic shock than ALT.