Summary

•  The Argutus Medical OxyDNA Test can detect toxicity in cell culture systems.

   

Selected Articles

1) Casuarinin protects cultured MDCK cells from hydrogen peroxide-induced oxidative stress and DNA oxidative damage.
Chen, C.-H., Liu, T.-Z., Kuo, T.-C., Lu, F.-J., Chen, Y.-C., Chang-Chien, Y.-W. and Lin, C.-C. (2004). Planta Med. 70(11) 1022-6.

• The drug Casuarinin could protect cultured renal cells from oxidative stress as shown by reduced 8-oxoguanine staining.

2) Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells
Lai, K.N. Chan, L.Y.Y., Tang S.C.W. and Leung, J.C.K. (2006). Nephrol. Dial. Transplant. 21 1188–1197.

• Human Serum Albumin (HSA) induces oxidative DNA damage which can be reduced by Ganoderma extract.

3) Using cryopreserved neuronal cells for multiwell neurotoxicity assays
Tinner-Staines, B., VandenHoek, S., Major, N., Krantis, A. and Staines, W. Poster presented at the Society for Neuroscience, October 2004 annual meeting

• Neuronal cultures could be used to study the effect of potential oxidizing agents