Summary

• The Argutus Medical OxyDNA Test can be used to detect the effects of UV light on keratinocyte cultures.

Selected Articles

1) Heat shock inhibits UVA-induced cell death
Der-Petrossian M, Klosner G, Kokesch C, Merwald H, Hönigsamnn H, Trautinger F. 2004.Abstract number: 304, 34th Annual European Society for Dermatological Research (ESDR) Meeting Vienna, 9-11 September, 2004.

• Pre-exposure of keratinocytes to heat increased their resistance to UV light induced oxidative DNA damage.

2) Relevance of reactive oxygen species in the induction of 8-oxo-2’-deoxyguanosine in HaCaT keratinocytes
Riemschneider, S., Podhaisky, H.P. Klapperstueck, T. and Wohlrab, W. (2002). Acta Derm. Venereol. 82 325-328.

• A valuable acount of how to reproducibly induce oxidative DNA damage in keratinocytes.

• The Argutus Medical OxyDNA Test is a valuable tool for studying cutaneous UV damage.